CMap Candidate Details

Structure:
CMap ID: C28799
Pert ID: BRD-K83057217
Compound Name: doxifluridine
Targets: TYMS
MoA: Thymidylate synthase inhibitor
SMILES: C[C@H]1O[C@H]([C@@H](O)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O
InchiKey: ZWAOHEXOSAUJHY-YQHTUYAKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96615 BRD-K83057217 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126032 BRD-K83057217 HELA 0.37 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
126055 BRD-K83057217 HT29 0.04 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
126132 BRD-K83057217 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126185 BRD-K83057217 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126222 BRD-K83057217 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.22
126303 BRD-K83057217 THP1 10 uM 24 h 0.24 1.02 0.12 0.27 0.94 0.3
134039 BRD-K83057217 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134068 BRD-K83057217 HA1E 0.03 uM 24 h 0.24 1.02 0.12 -0.19 -0.65 0.01
134106 BRD-K83057217 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134207 BRD-K83057217 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134260 BRD-K83057217 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134287 BRD-K83057217 PC3 0.01 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
134315 BRD-K83057217 YAPC 0.01 uM 24 h 0.27 1.13 0.28 -0.27 -0.92 0.33
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).