CMap Candidate Details

Structure:
CMap ID: C28903
Pert ID: BRD-K83405785
Compound Name: pimavanserin
Targets: HTR2A
MoA: Serotonin receptor inverse agonist
SMILES: CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1
InchiKey: RKEWSXXUOLRFBX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125558 BRD-K83405785 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125601 BRD-K83405785 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125624 BRD-K83405785 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125663 BRD-K83405785 HELA 0.04 uM 24 h -0.26 -1.09 0.31 0.0 0.0 0.0
125687 BRD-K83405785 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125706 BRD-K83405785 HUVEC 10 uM 24 h -0.22 -0.91 0.06 -0.32 -1.07 0.76
125814 BRD-K83405785 MCF??7.00 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
125839 BRD-K83405785 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125861 BRD-K83405785 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
125905 BRD-K83405785 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133720 BRD-K83405785 HEK293 0.03 uM 24 h 0.16 0.68 0.0 0.0 0.0 0.0
133814 BRD-K83405785 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
133839 BRD-K83405785 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133960 BRD-K83405785 THP1 2.22 uM 24 h 0.22 0.9 0.02 0.24 0.86 0.16
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).