CMap Candidate Details

Structure:
CMap ID: C28974
Pert ID: BRD-K83636919
Compound Name: entacapone
Targets: COMT
MoA: Catechol O methyltransferase inhibitor
SMILES: CCN(CC)C(=O)C(C#N)=Cc1cc(O)c(O)c(c1)[N+]([O-])=O
InchiKey: JRURYQJSLYLRLN-BJMVGYQFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49899 BRD-K83636919 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50248 BRD-K83636919 HA1E 10 uM 6 h 0.19 0.81 0.0 0.23 0.81 0.09
50597 BRD-K83636919 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50690 BRD-K83636919 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.62
50867 BRD-K83636919 PC3 10 uM 24 h 0.16 0.69 0.0 -0.37 -1.23 1.25
51185 BRD-K83636919 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91172 BRD-K83636919 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).