CMap Candidate Details

Structure:
CMap ID: C28975
Pert ID: BRD-K83637872
Compound Name: SANT-1
Targets: SHH; SMO
MoA: Smoothened receptor antagonist
SMILES: Cc1nn(c(C)c1C=NN2CCN(Cc3ccccc3)CC2)c4ccccc4
InchiKey: FOORCIAZMIWALX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1786 BRD-K83637872 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1987 BRD-K83637872 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2434 BRD-K83637872 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2516 BRD-K83637872 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39201 BRD-K83637872 A375 10 uM 6 h -0.28 -1.19 0.51 -0.29 -0.97 0.45
39503 BRD-K83637872 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39791 BRD-K83637872 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40083 BRD-K83637872 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40347 BRD-K83637872 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40516 BRD-K83637872 MCF??7.00 10 uM 24 h -0.19 -0.79 0.0 -0.32 -1.09 0.83
40890 BRD-K83637872 NEU 10 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
41211 BRD-K83637872 NPC 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
41550 BRD-K83637872 SKB 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.5
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).