CMap Candidate Details

Structure:
CMap ID: C28990
Pert ID: BRD-K83699324
Compound Name: NMS-1286937
Targets: PLK1
MoA: PLK inhibitor
SMILES: CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1
InchiKey: QHLVBNKYJGBCQJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90855 BRD-K83699324 MCF10A 10 uM 12 h 0.0 0.0 0.0 0.0 0.0 0.0
126007 BRD-K83699324 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126133 BRD-K83699324 JURKAT 1.11 uM 24 h -0.2 -0.84 0.0 -0.26 -0.87 0.23
126304 BRD-K83699324 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.14
134010 BRD-K83699324 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134040 BRD-K83699324 A549 0.74 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
134107 BRD-K83699324 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.71
134152 BRD-K83699324 HELA 0.08 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
134184 BRD-K83699324 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134208 BRD-K83699324 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134230 BRD-K83699324 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.94
134261 BRD-K83699324 MDAMB231 2.22 uM 24 h -0.27 -1.13 0.41 0.0 0.0 0.0
134288 BRD-K83699324 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.31
134316 BRD-K83699324 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).