CMap Candidate Details

Structure:
CMap ID: C28998
Pert ID: BRD-K83720053
Compound Name: avagacestat
Targets: --
MoA: --
SMILES: NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1
InchiKey: XEAOPVUAMONVLA-QGZVFWFLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96764 BRD-K83720053 PC3 10 uM 24 h -0.2 -0.82 0.0 -0.21 -0.72 0.04
118527 BRD-K83720053 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118572 BRD-K83720053 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.46
118609 BRD-K83720053 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.56
126010 BRD-K83720053 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126136 BRD-K83720053 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126189 BRD-K83720053 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126307 BRD-K83720053 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.03 0.62
134013 BRD-K83720053 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134043 BRD-K83720053 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134111 BRD-K83720053 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134156 BRD-K83720053 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134209 BRD-K83720053 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134232 BRD-K83720053 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134264 BRD-K83720053 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134318 BRD-K83720053 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).