CMap Candidate Details

Structure:
CMap ID: C29086
Pert ID: BRD-K83972459
Compound Name: JWE-035
Targets: AURKA
MoA: Aurora kinase inhibitor
SMILES: CCN1CCN(Cc2ccc(Nc3ncc4N(C)C(=O)c5ccccc5N(C)c4n3)cc2C(F)(F)F)CC1
InchiKey: PXGLIUGVLBRUBV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33937 BRD-K83972459 A549 10 uM 6 h 0.25 1.06 0.19 0.32 1.12 0.78
34433 BRD-K83972459 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34699 BRD-K83972459 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.91 0.31
34976 BRD-K83972459 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35215 BRD-K83972459 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36366 BRD-K83972459 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36664 BRD-K83972459 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36881 BRD-K83972459 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91833 BRD-K83972459 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91852 BRD-K83972459 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91902 BRD-K83972459 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91973 BRD-K83972459 SKBR3 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.68
94404 BRD-K83972459 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94469 BRD-K83972459 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94530 BRD-K83972459 CD34 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
94624 BRD-K83972459 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94674 BRD-K83972459 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94723 BRD-K83972459 HME1 10 uM 24 h 0.25 1.06 0.18 -0.36 -1.2 1.17
94819 BRD-K83972459 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94871 BRD-K83972459 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.71
94966 BRD-K83972459 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
94998 BRD-K83972459 NEU 10 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
95046 BRD-K83972459 NPC 1.11 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
95105 BRD-K83972459 PC3 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
95143 BRD-K83972459 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95195 BRD-K83972459 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95256 BRD-K83972459 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).