CMap Candidate Details

Structure:
CMap ID: C02917
Pert ID: BRD-K01621533
Compound Name: acarbose
Targets: GAA; AMY2A; MGAM
MoA: Glucosidase inhibitor
SMILES: C[C@@H]1O[C@H](O[C@@H]2[C@H](CO)O[C@H](O[C@@H]3[C@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@@H]1O
InchiKey: XUFXOAAUWZOOIT-PCKYEMPFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122894 BRD-K01621533 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
123019 BRD-K01621533 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
123108 BRD-K01621533 MDAMB231 0.37 uM 24 h 0.25 1.04 0.15 0.37 1.3 1.49
123180 BRD-K01621533 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
131207 BRD-K01621533 A375 0.01 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
131243 BRD-K01621533 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131279 BRD-K01621533 HA1E 0.25 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
131304 BRD-K01621533 HELA 0.01 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
131325 BRD-K01621533 HT29 0.03 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.68
131356 BRD-K01621533 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
131396 BRD-K01621533 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131435 BRD-K01621533 MCF??7.00 0.03 uM 24 h 0.26 1.06 0.19 0.0 0.0 0.0
131462 BRD-K01621533 PC3 2.22 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
131495 BRD-K01621533 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.41
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).