CMap Candidate Details

Structure:
CMap ID: C29252
Pert ID: BRD-K84564571
Compound Name: telatinib
Targets: KDR
MoA: KIT inhibitor; PDGFR inhibitor; VEGFR inhibitor
SMILES: CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1
InchiKey: QFCXANHHBCGMAS-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125562 BRD-K84564571 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125625 BRD-K84564571 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125711 BRD-K84564571 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
125793 BRD-K84564571 MCF10A 3.33 uM 24 h -0.32 -1.34 0.98 0.0 0.0 0.0
125818 BRD-K84564571 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125842 BRD-K84564571 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.42 1.5 2.26
125864 BRD-K84564571 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125888 BRD-K84564571 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125910 BRD-K84564571 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133657 BRD-K84564571 A549 0.74 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
133724 BRD-K84564571 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133751 BRD-K84564571 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133784 BRD-K84564571 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
133817 BRD-K84564571 JURKAT 0.03 uM 24 h -0.29 -1.22 0.6 0.32 1.12 0.76
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).