CMap Candidate Details

Structure:
CMap ID: C29274
Pert ID: BRD-K84639753
Compound Name: safinamide
Targets: MAOB; SLC6A3
MoA: Glutamate inhibitor; Dopamine uptake inhibitor; Monoamine oxidase inhibitor
SMILES: C[C@@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
InchiKey: NEMGRZFTLSKBAP-GFCCVEGCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33606 BRD-K84639753 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33850 BRD-K84639753 A549 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
34195 BRD-K84639753 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34436 BRD-K84639753 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34702 BRD-K84639753 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34979 BRD-K84639753 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35218 BRD-K84639753 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35351 BRD-K84639753 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35629 BRD-K84639753 NEU 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
35853 BRD-K84639753 NPC 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
36005 BRD-K84639753 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36369 BRD-K84639753 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36667 BRD-K84639753 SKB 10 uM 24 h -0.34 -1.42 1.43 0.0 0.0 0.0
36883 BRD-K84639753 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).