CMap Candidate Details

Structure:
CMap ID: C29298
Pert ID: BRD-K84709232
Compound Name: caffeic-acid
Targets: ALOX5
MoA: Lipoxygenase inhibitor; NFKB pathway inhibitor; HIV integrase inhibitor; PPAR receptor modulator; TNF production inhibitor; Nitric oxide production inhibitor; Tumor necrosis factor production inhibitor
SMILES: Oc1ccc(C=CC(=O)OCCc2ccccc2)cc1O
InchiKey: SWUARLUWKZWEBQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1643 BRD-K84709232 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1991 BRD-K84709232 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2158 BRD-K84709232 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2642 BRD-K84709232 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39506 BRD-K84709232 A549 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.45
39795 BRD-K84709232 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40087 BRD-K84709232 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40351 BRD-K84709232 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40520 BRD-K84709232 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40894 BRD-K84709232 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41215 BRD-K84709232 NPC 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
41554 BRD-K84709232 SKB 10 uM 24 h -0.19 -0.8 0.0 -0.22 -0.74 0.05
97297 BRD-K84709232 HAP1 0.66 uM 24 h 0.25 1.05 0.17 0.26 0.94 0.28
97342 BRD-K84709232 A375 0.66 uM 24 h 0.31 1.29 0.64 0.28 0.99 0.4
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).