CMap Candidate Details

Structure:
CMap ID: C29310
Pert ID: BRD-K84748119
Compound Name: vicriviroc
Targets: CCR5
MoA: CCK receptor antagonist
SMILES: COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F
InchiKey: CNPVJJQCETWNEU-CYFREDJKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125583 BRD-K84748119 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.43
125735 BRD-K84748119 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
125778 BRD-K84748119 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
125828 BRD-K84748119 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125851 BRD-K84748119 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125875 BRD-K84748119 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125894 BRD-K84748119 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125933 BRD-K84748119 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133668 BRD-K84748119 A549 0.74 uM 24 h 0.0 0.0 0.0 0.19 0.69 0.01
133699 BRD-K84748119 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133731 BRD-K84748119 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133767 BRD-K84748119 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.3
133800 BRD-K84748119 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
133857 BRD-K84748119 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).