CMap Candidate Details

Structure:
CMap ID: C29320
Pert ID: BRD-K84783599
Compound Name: riociguat
Targets: GUCY1A1; GUCY1B1
MoA: Guanylate cyclase stimulant
SMILES: COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12
InchiKey: WXXSNCNJFUAIDG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126013 BRD-K84783599 HA1E 0.125 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
126095 BRD-K84783599 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.72
126143 BRD-K84783599 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
126196 BRD-K84783599 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126314 BRD-K84783599 THP1 3.33 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
126345 BRD-K84783599 YAPC 1.11 uM 24 h -0.24 -0.99 0.13 -0.26 -0.88 0.26
134018 BRD-K84783599 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134046 BRD-K84783599 A549 0.25 uM 24 h -0.22 -0.93 0.07 -0.25 -0.85 0.19
134117 BRD-K84783599 HEK293 2.22 uM 24 h 0.25 1.04 0.14 0.34 1.2 1.12
134160 BRD-K84783599 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134190 BRD-K84783599 HT29 0.03 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.59
134237 BRD-K84783599 MCF??7.00 0.25 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
134271 BRD-K84783599 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
134294 BRD-K84783599 PC3 0.74 uM 24 h 0.18 0.73 0.0 -0.34 -1.15 1.08
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).