CMap Candidate Details

Structure:
CMap ID: C29335
Pert ID: BRD-K84810405
Compound Name: almorexant
Targets: HCRTR1; HCRTR2
MoA: Orexin receptor antagonist
SMILES: CNC(=O)[C@H](N1CCc2cc(OC)c(OC)cc2[C@@H]1CCc1ccc(cc1)C(F)(F)F)c1ccccc1
InchiKey: DKMACHNQISHMDN-RPLLCQBOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126093 BRD-K84810405 HUVEC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126141 BRD-K84810405 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126194 BRD-K84810405 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126312 BRD-K84810405 THP1 0.04 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
134016 BRD-K84810405 A375 0.74 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
134045 BRD-K84810405 A549 0.01 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
134073 BRD-K84810405 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134115 BRD-K84810405 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134158 BRD-K84810405 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134189 BRD-K84810405 HT29 0.74 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
134235 BRD-K84810405 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134269 BRD-K84810405 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134292 BRD-K84810405 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.4 1.42 2.19
134323 BRD-K84810405 YAPC 0.25 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).