CMap Candidate Details

Structure:
CMap ID: C29385
Pert ID: BRD-K84987553
Compound Name: MDM2-inhibitor
Targets: MDM2
MoA: MDM inhibitor
SMILES: OB(O)c1ccc(cc1)C(=O)/C=C/c2ccc(I)cc2
InchiKey: BYMGWCQXSPGCMW-XCVCLJGOSA-N
Compound Aliases: MDM-2-INHIBITOR

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1644 BRD-K84987553 HA1E 10 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
1992 BRD-K84987553 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2437 BRD-K84987553 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2721 BRD-K84987553 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41850 BRD-K84987553 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42151 BRD-K84987553 A549 10 uM 6 h -0.24 -0.99 0.13 0.0 0.0 0.0
42486 BRD-K84987553 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42796 BRD-K84987553 HEPG2 10 uM 6 h 0.18 0.77 0.0 0.0 0.0 0.0
43088 BRD-K84987553 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43360 BRD-K84987553 MCF??7.00 10 uM 6 h -0.23 -0.97 0.11 0.0 0.0 0.0
43661 BRD-K84987553 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43961 BRD-K84987553 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44213 BRD-K84987553 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).