CMap Candidate Details

Structure:
CMap ID: C29414
Pert ID: BRD-K85090592
Compound Name: pilocarpine
Targets: CHRM1; CHRM2; CHRM3
MoA: Acetylcholine receptor agonist
SMILES: CC[C@H]1[C@@H](Cc2cncn2C)COC1=O
InchiKey: QCHFTSOMWOSFHM-WPRPVWTQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24817 BRD-K85090592 HA1E 10 uM 6 h 0.0 0.0 0.0 0.3 1.06 0.58
25539 BRD-K85090592 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.82 0.14
91097 BRD-K85090592 HUH7 15 uM 72 h 0.28 1.18 0.39 -0.32 -1.08 0.8
125568 BRD-K85090592 A375 0.04 uM 24 h 0.21 0.89 0.02 0.26 0.92 0.25
125606 BRD-K85090592 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125669 BRD-K85090592 HELA 1.11 uM 24 h 0.23 0.98 0.09 -0.25 -0.83 0.17
125717 BRD-K85090592 HUVEC 3.33 uM 24 h 0.34 1.43 1.1 0.0 0.0 0.0
125766 BRD-K85090592 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
125821 BRD-K85090592 MCF??7.00 10 uM 24 h -0.25 -1.02 0.18 0.24 0.87 0.17
125845 BRD-K85090592 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125866 BRD-K85090592 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125890 BRD-K85090592 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125916 BRD-K85090592 YAPC 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
133727 BRD-K85090592 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133789 BRD-K85090592 HT29 0.74 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.69
133846 BRD-K85090592 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).