CMap Candidate Details

Structure:
CMap ID: C29508
Pert ID: BRD-K85402309
Compound Name: dovitinib
Targets: EGFR; FGFR1; FGFR3; FGFR2; FLT1; FLT3; FLT4; KDR; KIT; PDGFRB
MoA: EGFR inhibitor; FGFR inhibitor; FLT3 inhibitor; PDGFR inhibitor; VEGFR inhibitor
SMILES: CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
InchiKey: BAWMTQUBRCAWFL-ZZEZOPTASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
39 BRD-K85402309 BJAB 10 uM 4 h -0.22 -0.93 0.07 0.23 0.81 0.09
108 BRD-K85402309 HBL1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
142 BRD-K85402309 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
160 BRD-K85402309 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
203 BRD-K85402309 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
241 BRD-K85402309 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
280 BRD-K85402309 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 -0.21 -0.69 0.03
320 BRD-K85402309 OCILY3 0.04 uM 24 h 0.0 0.0 0.0 0.17 0.61 0.0
359 BRD-K85402309 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.56
398 BRD-K85402309 THP1 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.52
434 BRD-K85402309 TMD8 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33658 BRD-K85402309 A375 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.13
33851 BRD-K85402309 A549 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
34197 BRD-K85402309 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34437 BRD-K85402309 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34980 BRD-K85402309 HEPG2 10 uM 6 h -0.22 -0.91 0.06 0.25 0.89 0.2
36669 BRD-K85402309 SKB 10 uM 24 h -0.22 -0.91 0.06 0.25 0.87 0.17
36885 BRD-K85402309 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91853 BRD-K85402309 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91885 BRD-K85402309 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92038 BRD-K85402309 BT20 10 uM 3 h 0.0 0.0 0.0 -0.56 -1.87 15.65
92092 BRD-K85402309 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
92130 BRD-K85402309 HS578T 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
92184 BRD-K85402309 HT29 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.82
92306 BRD-K85402309 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92333 BRD-K85402309 PC3 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
92362 BRD-K85402309 SKBR3 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
96047 BRD-K85402309 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).