CMap Candidate Details

Structure:
CMap ID: C29509
Pert ID: BRD-K85406984
Compound Name: sobetirome
Targets: THRA; THRB
MoA: Thyroid hormone receptor agonist
SMILES: CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O
InchiKey: QNAZTOHXCZPOSA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126017 BRD-K85406984 HA1E 0.37 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
126100 BRD-K85406984 HUVEC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126151 BRD-K85406984 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.05
126202 BRD-K85406984 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126224 BRD-K85406984 MCF??7.00 3.33 uM 24 h 0.2 0.86 0.01 0.0 0.0 0.0
126246 BRD-K85406984 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
126273 BRD-K85406984 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126321 BRD-K85406984 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134022 BRD-K85406984 A375 0.01 uM 24 h -0.32 -1.31 0.82 0.0 0.0 0.0
134051 BRD-K85406984 A549 0.01 uM 24 h 0.33 1.36 0.97 0.0 0.0 0.0
134125 BRD-K85406984 HEK293 0.01 uM 24 h 0.32 1.33 0.85 -0.27 -0.92 0.32
134166 BRD-K85406984 HELA 0.03 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
134194 BRD-K85406984 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.91
134329 BRD-K85406984 YAPC 0.03 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).