CMap Candidate Details

Structure:
CMap ID: C29564
Pert ID: BRD-K85606544
Compound Name: neratinib
Targets: EGFR; ERBB2; ERBB4
MoA: EGFR inhibitor
SMILES: CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)C=CCN(C)C
InchiKey: JWNPDZNEKVCWMY-VQHVLOKHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4 BRD-K85606544 HEPG2 2.5 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
21 BRD-K85606544 NCIH508 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9246 BRD-K85606544 A549 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.85
9529 BRD-K85606544 AGS 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.38
9834 BRD-K85606544 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10088 BRD-K85606544 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10191 BRD-K85606544 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10611 BRD-K85606544 HCT116 10 uM 6 h 0.0 0.0 0.0 0.32 1.12 0.75
11596 BRD-K85606544 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.41 1.45 2.22
12153 BRD-K85606544 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12394 BRD-K85606544 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.37 1.32 1.6
12632 BRD-K85606544 PC3 10 uM 6 h 0.0 0.0 0.0 0.41 1.45 2.22
13036 BRD-K85606544 THP1 10 uM 6 h 0.22 0.92 0.04 0.3 1.05 0.58
13377 BRD-K85606544 U937 10 uM 6 h 0.16 0.68 0.0 0.0 0.0 0.0
13510 BRD-K85606544 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91715 BRD-K85606544 MDAMB231 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91780 BRD-K85606544 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92036 BRD-K85606544 BT20 10 uM 3 h 0.0 0.0 0.0 0.42 1.48 2.25
92122 BRD-K85606544 HS578T 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92175 BRD-K85606544 HT29 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
92227 BRD-K85606544 MCF10A 0.37 uM 3 h 0.0 0.0 0.0 0.41 1.47 2.24
92247 BRD-K85606544 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125970 BRD-K85606544 A375 1.11 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
126099 BRD-K85606544 HUVEC 10 uM 24 h -0.35 -1.45 1.43 0.0 0.0 0.0
126149 BRD-K85606544 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
134123 BRD-K85606544 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
134164 BRD-K85606544 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
134327 BRD-K85606544 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).