CMap Candidate Details

Structure:
CMap ID: C00296
Pert ID: BRD-A11678676
Compound Name: wortmannin
Targets: PIK3CA; PIK3CG; PLK1
MoA: PI3K inhibitor
SMILES: COC[C@H]1OC(=O)c2coc3C(=O)C4=C([C@@H](C[C@@]5(C)C4CCC5=O)OC(=O)C)[C@]1(C)c23
InchiKey: QDLHCMPXEPAAMD-ZGSWIPFCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5387 BRD-A11678676 HA1E 10 uM 6 h -0.28 -1.18 0.5 0.0 0.0 0.0
5497 BRD-A11678676 HCC515 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
5824 BRD-A11678676 HEPG2 10 uM 6 h 0.31 1.27 0.58 -0.26 -0.87 0.23
6235 BRD-A11678676 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6310 BRD-A11678676 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39262 BRD-A11678676 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39548 BRD-A11678676 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40164 BRD-A11678676 HT29 10 uM 6 h -0.21 -0.87 0.02 0.29 1.02 0.47
40558 BRD-A11678676 MCF??7.00 10 uM 6 h -0.17 -0.73 0.0 0.0 0.0 0.0
40681 BRD-A11678676 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40974 BRD-A11678676 NPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.68
41298 BRD-A11678676 SKB 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
97310 BRD-A11678676 HAP1 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
97364 BRD-A11678676 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).