CMap Candidate Details

Structure:
CMap ID: C29612
Pert ID: BRD-K85751432
Compound Name: refametinib
Targets: MAP2K1; MAP2K2
MoA: MEK inhibitor
SMILES: COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1
InchiKey: RDSACQWTXKSHJT-NSHDSACASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95349 BRD-K85751432 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95425 BRD-K85751432 U2OS 10 uM 48 h 0.0 0.0 0.0 0.26 0.91 0.23
125572 BRD-K85751432 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
125643 BRD-K85751432 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125692 BRD-K85751432 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
125721 BRD-K85751432 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125867 BRD-K85751432 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125920 BRD-K85751432 YAPC 10 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
133660 BRD-K85751432 A549 2.22 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.59
133692 BRD-K85751432 HA1E 0.25 uM 24 h 0.29 1.2 0.42 0.22 0.79 0.07
133756 BRD-K85751432 HELA 2.22 uM 24 h 0.24 1.01 0.12 0.37 1.31 1.59
133821 BRD-K85751432 JURKAT 2.22 uM 24 h 0.22 0.91 0.03 -0.28 -0.93 0.35
133849 BRD-K85751432 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133905 BRD-K85751432 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133969 BRD-K85751432 THP1 2.22 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).