CMap Candidate Details

Structure:
CMap ID: C29646
Pert ID: BRD-K85853281
Compound Name: BRD-K85853281
Targets: TOP2A
MoA: Topoisomerase inhibitor
SMILES: C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@@H]1C[C@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O
InchiKey: XDXDZDZNSLXDNA-LGVQOGFTSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
21922 BRD-K85853281 A375 10 uM 6 h 0.0 0.0 0.0 0.33 1.16 0.9
22169 BRD-K85853281 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
22580 BRD-K85853281 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22864 BRD-K85853281 HCC515 10 uM 6 h 0.0 0.0 0.0 0.43 1.53 2.3
23167 BRD-K85853281 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23455 BRD-K85853281 HT29 10 uM 6 h 0.0 0.0 0.0 0.37 1.3 1.49
23646 BRD-K85853281 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
23902 BRD-K85853281 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115200 BRD-K85853281 U2OS 20 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).