CMap Candidate Details

Structure:
CMap ID: C29693
Pert ID: BRD-K85985071
Compound Name: ellipticine
Targets: TOP2A; TOP2B
MoA: Topoisomerase inhibitor
SMILES: Cc1c2[nH]c3ccccc3c2c(C)c4cnccc14
InchiKey: CTSPAMFJBXKSOY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33701 BRD-K85985071 A375 10 uM 6 h -0.22 -0.93 0.07 0.0 0.0 0.0
33940 BRD-K85985071 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34199 BRD-K85985071 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34439 BRD-K85985071 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.22 1.25
34704 BRD-K85985071 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35220 BRD-K85985071 HT29 10 uM 6 h 0.21 0.87 0.01 -0.24 -0.81 0.13
35474 BRD-K85985071 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35631 BRD-K85985071 NEU 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
35855 BRD-K85985071 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36112 BRD-K85985071 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36671 BRD-K85985071 SKB 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
37013 BRD-K85985071 VCAP 10 uM 6 h 0.2 0.85 0.01 -0.32 -1.08 0.81
53482 BRD-K85985071 HEPG2 2.5 uM 6 h -0.21 -0.86 0.02 -0.23 -0.79 0.1
53620 BRD-K85985071 HUH7 2.5 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.52
53698 BRD-K85985071 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).