CMap Candidate Details

Structure:
CMap ID: C29785
Pert ID: BRD-K86301799
Compound Name: dipyridamole
Targets: ADA; PDE10A; SLC29A1; PDE7B; PDE4A; PDE8A; PDE8B; PDE5A
MoA: Phosphodiesterase inhibitor
SMILES: OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
InchiKey: IZEKFCXSFNUWAM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5691 BRD-K86301799 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
6597 BRD-K86301799 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42488 BRD-K86301799 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42798 BRD-K86301799 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43663 BRD-K86301799 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43963 BRD-K86301799 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44215 BRD-K86301799 SKB 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
50069 BRD-K86301799 A549 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.24
91151 BRD-K86301799 HUH7 6.66 uM 72 h -0.27 -1.13 0.4 -0.23 -0.78 0.1
96988 BRD-K86301799 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124333 BRD-K86301799 HEK293 10 uM 24 h 0.37 1.53 1.45 0.0 0.0 0.0
124372 BRD-K86301799 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
124442 BRD-K86301799 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124503 BRD-K86301799 MDAMB231 10 uM 24 h -0.26 -1.07 0.27 -0.23 -0.78 0.09
124565 BRD-K86301799 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132403 BRD-K86301799 HA1E 0.25 uM 24 h 0.0 0.0 0.0 -0.43 -1.43 15.35
132476 BRD-K86301799 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132512 BRD-K86301799 MCF10A 0.74 uM 24 h 0.3 1.24 0.53 0.22 0.78 0.06
132541 BRD-K86301799 MCF??7.00 0.01 uM 24 h -0.25 -1.06 0.26 0.0 0.0 0.0
132579 BRD-K86301799 PC3 0.01 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
132631 BRD-K86301799 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).