CMap Candidate Details

Structure:
CMap ID: C29836
Pert ID: BRD-K86525559
Compound Name: AZD-7762
Targets: CHEK1; CHEK2
MoA: CHK inhibitor
SMILES: NC(=O)Nc1cc(sc1C(=O)N[C@H]1CCCNC1)-c1cccc(F)c1
InchiKey: IAYGCINLNONXHY-LBPRGKRZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
116427 BRD-K86525559 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116479 BRD-K86525559 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116529 BRD-K86525559 HT29 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
116615 BRD-K86525559 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125974 BRD-K86525559 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125992 BRD-K86525559 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126022 BRD-K86525559 HA1E 0.37 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
126041 BRD-K86525559 HELA 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
126158 BRD-K86525559 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126209 BRD-K86525559 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
126226 BRD-K86525559 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126250 BRD-K86525559 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126328 BRD-K86525559 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134132 BRD-K86525559 HEK293 0.74 uM 24 h 0.3 1.24 0.53 0.0 0.0 0.0
134216 BRD-K86525559 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134334 BRD-K86525559 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).