CMap Candidate Details

Structure:
CMap ID: C29879
Pert ID: BRD-K86682249
Compound Name: BRD-K86682249
Targets: PTPN1
MoA: Tyrosine phosphatase inhibitor
SMILES: OC(=O)c1ccccc1c2ccc(C=c3sc4nc5cc(Br)cnc5n4c3=O)o2
InchiKey: NMLOLMOZTQCQJF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9001 BRD-K86682249 A375 10 uM 24 h 0.26 1.07 0.19 0.33 1.18 0.97
9837 BRD-K86682249 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10090 BRD-K86682249 HA1E 10 uM 6 h 0.27 1.13 0.29 0.0 0.0 0.0
10614 BRD-K86682249 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10866 BRD-K86682249 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.82 0.14
11029 BRD-K86682249 HT29 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.62
11124 BRD-K86682249 MCF??7.00 10 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
11599 BRD-K86682249 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11858 BRD-K86682249 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12156 BRD-K86682249 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.34 1.2 1.09
12424 BRD-K86682249 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12886 BRD-K86682249 SW480 10 uM 6 h 0.22 0.94 0.06 0.0 0.0 0.0
12923 BRD-K86682249 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13380 BRD-K86682249 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13694 BRD-K86682249 VCAP 10 uM 6 h -0.28 -1.17 0.48 0.4 1.41 2.19
14345 BRD-K86682249 A549 10 uM 6 h -0.2 -0.82 0.0 0.0 0.0 0.0
14906 BRD-K86682249 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115202 BRD-K86682249 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).