CMap Candidate Details

Structure:
CMap ID: C29946
Pert ID: BRD-K86882815
Compound Name: cabergoline
Targets: ADRA1A; ADRA2A; ADRA2B; ADRA2C; DRD1; DRD2; DRD3; DRD4; DRD5; HTR1A; HTR1B; HTR1D; HTR2A; HTR2B; HTR2C
MoA: Dopamine receptor agonist
SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(CC=C)C1
InchiKey: KORNTPPJEAJQIU-KJXAQDMKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1647 BRD-K86882815 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
1997 BRD-K86882815 HCC515 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.28
2771 BRD-K86882815 VCAP 10 uM 6 h 0.23 0.97 0.08 0.28 0.99 0.39
42799 BRD-K86882815 HEPG2 10 uM 6 h -0.22 -0.93 0.07 0.0 0.0 0.0
43664 BRD-K86882815 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
43964 BRD-K86882815 PHH 10 uM 24 h -0.24 -1.0 0.15 0.27 0.95 0.32
91200 BRD-K86882815 HUH7 8 uM 72 h 0.0 0.0 0.0 0.35 1.23 1.22
126105 BRD-K86882815 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
126160 BRD-K86882815 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.42
126211 BRD-K86882815 MCF10A 0.04 uM 24 h 0.24 1.02 0.12 0.0 0.0 0.0
126330 BRD-K86882815 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134026 BRD-K86882815 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134057 BRD-K86882815 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134134 BRD-K86882815 HEK293 0.08 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
134170 BRD-K86882815 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134199 BRD-K86882815 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.39 1.37 2.12
134247 BRD-K86882815 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.41 1.43 2.21
134279 BRD-K86882815 MDAMB231 0.01 uM 24 h 0.21 0.86 0.01 -0.29 -0.99 0.5
134300 BRD-K86882815 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134335 BRD-K86882815 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).