CMap Candidate Details

Structure:
CMap ID: C30058
Pert ID: BRD-K87142802
Compound Name: veliparib
Targets: PARP2; PARP1
MoA: PARP inhibitor
SMILES: C[C@@]1(CCCN1)c1nc2c(cccc2[nH]1)C(N)=O
InchiKey: JNAHVYVRKWKWKQ-CYBMUJFWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9248 BRD-K87142802 A549 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
9531 BRD-K87142802 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11859 BRD-K87142802 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12447 BRD-K87142802 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12887 BRD-K87142802 SW480 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.86
13695 BRD-K87142802 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90586 BRD-K87142802 MCF??7.00 0.004 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
93743 BRD-K87142802 HA1E 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93777 BRD-K87142802 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93868 BRD-K87142802 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93950 BRD-K87142802 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.35 1.26 1.29
94081 BRD-K87142802 NEU 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94212 BRD-K87142802 SHSY5Y 0.12 uM 24 h -0.26 -1.07 0.28 -0.19 -0.64 0.01
94361 BRD-K87142802 YAPC 0.12 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.5
94427 BRD-K87142802 A375 0.04 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
94498 BRD-K87142802 ASC 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
94574 BRD-K87142802 CD34 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94662 BRD-K87142802 HEK293 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94769 BRD-K87142802 HME1 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.72
94807 BRD-K87142802 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94912 BRD-K87142802 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94956 BRD-K87142802 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
95097 BRD-K87142802 NPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95247 BRD-K87142802 SKL 0.37 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.43
95296 BRD-K87142802 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117522 BRD-K87142802 HEPG2 10 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).