CMap Candidate Details

Structure:
CMap ID: C30061
Pert ID: BRD-K87158025
Compound Name: benzamil
Targets: SCNN1A; SCNN1B; SCNN1D; SCNN1G; SLC8A1; PKD2L1
MoA: Sodium channel blocker
SMILES: NC(NCc1ccccc1)=NC(=O)c1nc(Cl)c(N)nc1N
InchiKey: KXDROGADUISDGY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3063 BRD-K87158025 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3401 BRD-K87158025 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3984 BRD-K87158025 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44455 BRD-K87158025 A375 10 uM 6 h 0.0 0.0 0.0 0.34 1.21 1.15
44625 BRD-K87158025 A549 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.42
45043 BRD-K87158025 ASC 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
45331 BRD-K87158025 HEPG2 10 uM 6 h -0.19 -0.79 0.0 0.0 0.0 0.0
45590 BRD-K87158025 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45723 BRD-K87158025 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.02
46155 BRD-K87158025 NPC 10 uM 24 h 0.18 0.73 0.0 0.0 0.0 0.0
46796 BRD-K87158025 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51857 BRD-K87158025 PC3 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).