CMap Candidate Details

Structure:
CMap ID: C30076
Pert ID: BRD-K87202646
Compound Name: isoniazid
Targets: CYP1A2; CYP2C19; CYP2C8; CYP2E1; CYP3A4
MoA: Cyclooxygenase inhibitor; Enoyl-acyl-carrier protein reductase inhibitor
SMILES: NNC(=O)c1ccncc1
InchiKey: QRXWMOHMRWLFEY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
52618 BRD-K87202646 A549 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52786 BRD-K87202646 HEPG2 40 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
53373 BRD-K87202646 MCF10A 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91058 BRD-K87202646 HUH7 25 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
121724 BRD-K87202646 A375 0.04 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
121742 BRD-K87202646 HA1E 0.04 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
121774 BRD-K87202646 HELA 0.37 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.69
121805 BRD-K87202646 HT29 0.04 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
129846 BRD-K87202646 HEK293 0.03 uM 24 h -0.31 -1.28 0.77 0.23 0.82 0.1
130010 BRD-K87202646 MCF??7.00 0.08 uM 24 h -0.3 -1.23 0.63 0.0 0.0 0.0
130057 BRD-K87202646 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
130088 BRD-K87202646 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130128 BRD-K87202646 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130171 BRD-K87202646 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).