CMap Candidate Details

Structure:
CMap ID: C30147
Pert ID: BRD-K87426499
Compound Name: BRD-K87426499
Targets: CASP3
MoA: Caspase inhibitor
SMILES: COc1ccc(cc1C)S(=O)(=O)N(C)C[C@@H]2Oc3c(NC(=O)Nc4cccc5ccccc45)cccc3C(=O)N(C[C@H]2C)[C@@H](C)CO
InchiKey: APTVJNKPZZAJMD-FXZPAHAQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29965 BRD-K87426499 A375 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.4
30259 BRD-K87426499 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30577 BRD-K87426499 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30862 BRD-K87426499 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.24
31155 BRD-K87426499 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31469 BRD-K87426499 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31582 BRD-K87426499 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31938 BRD-K87426499 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32549 BRD-K87426499 NPC 10 uM 24 h 0.23 0.94 0.06 -0.42 -1.43 15.35
32681 BRD-K87426499 PC3 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
33161 BRD-K87426499 SKB 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
33513 BRD-K87426499 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.46
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).