CMap Candidate Details

Structure:
CMap ID: C30301
Pert ID: BRD-K87909389
Compound Name: alvocidib
Targets: CDK2; CDK4; CDK5; CDK6; CDK7; CDK8; CDK9; EGFR; PYGM; CDK1
MoA: CDK inhibitor
SMILES: CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
InchiKey: BIIVYFLTOXDAOV-YVEFUNNKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1360 BRD-K87909389 U2OS 0.12 uM 48 h -0.16 -0.65 0.0 0.0 0.0 0.0
26488 BRD-K87909389 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
27109 BRD-K87909389 HCC515 10 uM 6 h 0.0 0.0 0.0 0.37 1.32 1.71
28050 BRD-K87909389 NEU 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
28999 BRD-K87909389 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29340 BRD-K87909389 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33514 BRD-K87909389 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91556 BRD-K87909389 BT20 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91627 BRD-K87909389 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91717 BRD-K87909389 MDAMB231 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92551 BRD-K87909389 HME1 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92599 BRD-K87909389 HS578T 3.33 uM 3 h 0.0 0.0 0.0 0.44 1.56 2.33
92648 BRD-K87909389 LNCAP 0.04 uM 24 h -0.17 -0.7 0.0 0.0 0.0 0.0
92821 BRD-K87909389 SKBR3 0.04 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
95332 BRD-K87909389 A549 1.11 uM 6 h 0.0 0.0 0.0 -0.23 -0.76 0.07
95348 BRD-K87909389 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
95862 BRD-K87909389 NPC 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
119662 BRD-K87909389 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119748 BRD-K87909389 JURKAT 0.37 uM 24 h 0.18 0.74 0.0 -0.25 -0.83 0.17
127724 BRD-K87909389 A375 0.125 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
127841 BRD-K87909389 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127894 BRD-K87909389 HT29 0.125 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.04
127915 BRD-K87909389 HUVEC 0.125 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
128038 BRD-K87909389 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128064 BRD-K87909389 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135518 BRD-K87909389 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135542 BRD-K87909389 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).