CMap Candidate Details

Structure:
CMap ID: C30318
Pert ID: BRD-K87947369
Compound Name: tozasertib
Targets: FLT3; ABL1; JAK2; BCR; AURKA; AURKC; AURKB
MoA: JAK inhibitor; FLT3 inhibitor; Aurora kinase inhibitor; Abl kinase inhibitor
SMILES: CN1CCN(CC1)c2cc(Nc3cc(C)n[nH]3)nc(Sc4ccc(NC(=O)C5CC5)cc4)n2
InchiKey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9042 BRD-K87947369 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9249 BRD-K87947369 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9532 BRD-K87947369 AGS 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
9838 BRD-K87947369 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9942 BRD-K87947369 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10193 BRD-K87947369 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10615 BRD-K87947369 HCT116 10 uM 6 h 0.0 0.0 0.0 0.38 1.34 1.72
10867 BRD-K87947369 HEPG2 10 uM 6 h -0.24 -1.02 0.17 0.27 0.97 0.34
11091 BRD-K87947369 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.19
11199 BRD-K87947369 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
11600 BRD-K87947369 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.36 1.26 1.29
11860 BRD-K87947369 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.33 1.16 0.9
12157 BRD-K87947369 NCIH596 10 uM 6 h -0.31 -1.28 0.77 0.0 0.0 0.0
12397 BRD-K87947369 NOMO1 10 uM 6 h 0.23 0.94 0.06 0.34 1.19 1.02
12516 BRD-K87947369 PC3 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
12888 BRD-K87947369 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13038 BRD-K87947369 THP1 10 uM 6 h -0.18 -0.73 0.0 0.37 1.32 1.69
13381 BRD-K87947369 U937 10 uM 6 h 0.0 0.0 0.0 0.41 1.47 2.24
13511 BRD-K87947369 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).