CMap Candidate Details

Structure:
CMap ID: C30331
Pert ID: BRD-K87990216
Compound Name: piretanide
Targets: SLC12A1; SLC12A2
MoA: Glucocorticoid receptor agonist
SMILES: NS(=O)(=O)c1cc(cc(N2CCCC2)c1Oc1ccccc1)C(O)=O
InchiKey: UJEWTUDSLQGTOA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2001 BRD-K87990216 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2462 BRD-K87990216 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39359 BRD-K87990216 A549 10 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
39807 BRD-K87990216 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41227 BRD-K87990216 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
41567 BRD-K87990216 SKB 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
51998 BRD-K87990216 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121725 BRD-K87990216 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
129804 BRD-K87990216 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
129848 BRD-K87990216 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129881 BRD-K87990216 HELA 0.03 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
129902 BRD-K87990216 HT29 0.25 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
129927 BRD-K87990216 JURKAT 0.25 uM 24 h 0.2 0.82 0.0 -0.3 -1.0 0.53
129973 BRD-K87990216 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
130059 BRD-K87990216 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130089 BRD-K87990216 PC3 0.03 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
130130 BRD-K87990216 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130173 BRD-K87990216 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).