CMap Candidate Details

Structure:
CMap ID: C30383
Pert ID: BRD-K88172511
Compound Name: naltrexone
Targets: OPRD1; OPRK1; OPRM1
MoA: Opioid receptor antagonist
SMILES: Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
InchiKey: DQCKKXVULJGBQN-XFWGSAIBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6809 BRD-K88172511 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7034 BRD-K88172511 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7489 BRD-K88172511 HA1E 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.42
20145 BRD-K88172511 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20483 BRD-K88172511 HEPG2 10 uM 6 h 0.26 1.08 0.21 0.0 0.0 0.0
20792 BRD-K88172511 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20975 BRD-K88172511 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
21450 BRD-K88172511 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
21811 BRD-K88172511 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91167 BRD-K88172511 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).