CMap Candidate Details

Structure:
CMap ID: C30447
Pert ID: BRD-K88366685
Compound Name: trimetazidine
Targets: ACAA2
MoA: 3-ketoacyl CoA thiolase inhibitor
SMILES: COc1ccc(CN2CCNCC2)c(OC)c1OC
InchiKey: UHWVSEOVJBQKBE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127726 BRD-K88366685 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127766 BRD-K88366685 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127843 BRD-K88366685 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.84
127895 BRD-K88366685 HT29 1.11 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
127917 BRD-K88366685 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
127971 BRD-K88366685 MCF10A 3.33 uM 24 h 0.22 0.94 0.05 0.0 0.0 0.0
135519 BRD-K88366685 HA1E 0.74 uM 24 h -0.29 -1.2 0.55 0.0 0.0 0.0
135544 BRD-K88366685 HELA 0.01 uM 24 h -0.21 -0.88 0.03 -0.28 -0.94 0.38
135635 BRD-K88366685 JURKAT 0.74 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
135685 BRD-K88366685 MCF??7.00 0.25 uM 24 h 0.24 0.99 0.09 0.0 0.0 0.0
135710 BRD-K88366685 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135734 BRD-K88366685 YAPC 0.74 uM 24 h 0.23 0.95 0.07 -0.23 -0.79 0.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).