CMap Candidate Details

Structure:
CMap ID: C30452
Pert ID: BRD-K88378636
Compound Name: withaferin-a
Targets: NAMPT; IKBKB
MoA: IKK inhibitor
SMILES: C[C@@H]([C@H]1CC[C@H]2[C@@H]3C[C@H]4O[C@]45[C@@H](O)C=CC(=O)[C@]5(C)[C@H]3CC[C@]12C)[C@H]6CC(=C(CO)C(=O)O6)C
InchiKey: DBRXOUCRJQVYJQ-CKNDUULBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
59932 BRD-K88378636 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.25 1.35
83533 BRD-K88378636 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
84747 BRD-K88378636 HT29 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
86491 BRD-K88378636 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
86980 BRD-K88378636 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90560 BRD-K88378636 MCF??7.00 0.37 uM 24 h 0.23 0.94 0.06 -0.24 -0.82 0.15
92017 BRD-K88378636 BT20 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92097 BRD-K88378636 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92136 BRD-K88378636 HS578T 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92498 BRD-K88378636 HA1E 0.37 uM 24 h -0.22 -0.91 0.05 0.24 0.86 0.16
92532 BRD-K88378636 HME1 0.12 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
92694 BRD-K88378636 LNCAP 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92732 BRD-K88378636 MCF10A 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92771 BRD-K88378636 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92850 BRD-K88378636 SKBR3 10 uM 3 h 0.0 0.0 0.0 -0.52 -1.74 15.65
100172 BRD-K88378636 U2OS 20 uM 6 h -0.28 -1.15 0.44 0.0 0.0 0.0
118708 BRD-K88378636 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119765 BRD-K88378636 JURKAT 0.37 uM 24 h -0.25 -1.02 0.18 0.0 0.0 0.0
136426 BRD-K88378636 SHSY5Y 0.125 uM 24 h -0.19 -0.78 0.0 0.27 0.96 0.33
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).