CMap Candidate Details

Structure:
CMap ID: C30484
Pert ID: BRD-K88510285
Compound Name: bortezomib
Targets: PSMB1; PSMB2; PSMB5
MoA: Proteasome inhibitor; NFKB pathway inhibitor
SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
InchiKey: GXJABQQUPOEUTA-RDJZCZTQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
501 BRD-K88510285 BJAB 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
557 BRD-K88510285 HBL1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
791 BRD-K88510285 OCILY19 0.125 uM 4 h 0.27 1.13 0.29 0.26 0.91 0.24
873 BRD-K88510285 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9002 BRD-K88510285 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9121 BRD-K88510285 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9533 BRD-K88510285 AGS 0.04 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9839 BRD-K88510285 H1299 0.04 uM 6 h 0.29 1.23 0.5 0.0 0.0 0.0
9971 BRD-K88510285 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10224 BRD-K88510285 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10616 BRD-K88510285 HCT116 0.04 uM 6 h 0.26 1.09 0.22 -0.36 -1.23 1.25
11601 BRD-K88510285 NCIH2073 0.04 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12158 BRD-K88510285 NCIH596 0.04 uM 6 h 0.22 0.9 0.03 -0.31 -1.05 0.71
12398 BRD-K88510285 NOMO1 0.04 uM 6 h 0.26 1.1 0.24 0.0 0.0 0.0
12889 BRD-K88510285 SW480 0.04 uM 6 h 0.31 1.28 0.63 0.0 0.0 0.0
13075 BRD-K88510285 THP1 0.04 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13382 BRD-K88510285 U937 0.04 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13696 BRD-K88510285 VCAP 0.04 uM 6 h 0.22 0.92 0.04 -0.33 -1.12 0.94
87386 BRD-K88510285 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87435 BRD-K88510285 KMS34 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87496 BRD-K88510285 MINO 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87538 BRD-K88510285 NALM6 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87688 BRD-K88510285 OCILY3 0.01 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
87861 BRD-K88510285 TMD8 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95450 BRD-K88510285 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97334 BRD-K88510285 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97818 BRD-K88510285 MCF??7.00 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116461 BRD-K88510285 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117891 BRD-K88510285 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127847 BRD-K88510285 HEK293 0.04 uM 24 h -0.22 -0.9 0.05 -0.35 -1.17 1.12
127921 BRD-K88510285 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127975 BRD-K88510285 MCF10A 0.04 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
128067 BRD-K88510285 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135548 BRD-K88510285 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135639 BRD-K88510285 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135711 BRD-K88510285 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).