CMap Candidate Details

Structure:
CMap ID: C30499
Pert ID: BRD-K88551539
Compound Name: CAY-10585
Targets: HIF1A
MoA: HIF modulator
SMILES: COC(=O)c1ccc(O)c(NC(=O)COc2ccc(cc2)C2C3CC4CC(C3)CC2C4)c1
InchiKey: CSCOJWVRGOZGPK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33725 BRD-K88551539 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33852 BRD-K88551539 A549 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
34203 BRD-K88551539 ASC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
34708 BRD-K88551539 HCC515 10 uM 6 h 0.19 0.81 0.0 0.21 0.75 0.04
34985 BRD-K88551539 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35223 BRD-K88551539 HT29 10 uM 6 h -0.22 -0.91 0.05 0.0 0.0 0.0
35354 BRD-K88551539 MCF??7.00 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
35634 BRD-K88551539 NEU 10 uM 24 h -0.24 -0.99 0.13 0.22 0.77 0.06
35858 BRD-K88551539 NPC 10 uM 24 h 0.23 0.95 0.06 -0.21 -0.69 0.02
36007 BRD-K88551539 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36375 BRD-K88551539 PHH 10 uM 24 h 0.16 0.68 0.0 0.0 0.0 0.0
36675 BRD-K88551539 SKB 10 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
37014 BRD-K88551539 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.89 0.26
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).