CMap Candidate Details

Structure:
CMap ID: C00305
Pert ID: BRD-A11990600
Compound Name: lorazepam
Targets: GABRA1; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ
MoA: Benzodiazepine receptor agonist
SMILES: OC1N=C(c2ccccc2Cl)c2cc(Cl)ccc2NC1=O
InchiKey: DIWRORZWFLOCLC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1142 BRD-A11990600 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1310 BRD-A11990600 MCF??7.00 0.12 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.14
1366 BRD-A11990600 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1420 BRD-A11990600 NPC 25 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
25122 BRD-A11990600 PC3 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
25466 BRD-A11990600 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
122233 BRD-A11990600 A375 10 uM 24 h -0.22 -0.93 0.07 -0.38 -1.29 1.53
122455 BRD-A11990600 THP1 10 uM 24 h 0.28 1.19 0.41 0.0 0.0 0.0
122505 BRD-A11990600 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130578 BRD-A11990600 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130608 BRD-A11990600 HEK293 0.08 uM 24 h -0.33 -1.37 1.08 0.0 0.0 0.0
130649 BRD-A11990600 HELA 0.74 uM 24 h 0.29 1.23 0.5 0.0 0.0 0.0
130689 BRD-A11990600 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130730 BRD-A11990600 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130774 BRD-A11990600 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).