CMap Candidate Details

Structure:
CMap ID: C30549
Pert ID: BRD-K88677950
Compound Name: PD-198306
Targets: MAP2K1; MAP2K2
MoA: MEK inhibitor; MAP kinase inhibitor
SMILES: Cc1cc(I)ccc1Nc1c(F)c(F)c(F)cc1C(=O)NOCC1CC1
InchiKey: UHAXDAKQGVISBZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2935 BRD-K88677950 HA1E 10 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
3281 BRD-K88677950 HCC515 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.36
3887 BRD-K88677950 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.05
39214 BRD-K88677950 A375 10 uM 6 h 0.0 0.0 0.0 0.23 0.8 0.08
39515 BRD-K88677950 A549 10 uM 6 h 0.0 0.0 0.0 -0.46 -1.56 15.65
39810 BRD-K88677950 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40365 BRD-K88677950 HT29 10 uM 6 h 0.0 0.0 0.0 0.38 1.36 1.72
40527 BRD-K88677950 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
40907 BRD-K88677950 NEU 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
41230 BRD-K88677950 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
41570 BRD-K88677950 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119672 BRD-K88677950 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119758 BRD-K88677950 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119830 BRD-K88677950 PC3 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.94
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).