CMap Candidate Details

Structure:
CMap ID: C30583
Pert ID: BRD-K88789588
Compound Name: letrozole
Targets: CYP19A1
MoA: Aromatase inhibitor
SMILES: N#Cc1ccc(cc1)C(c1ccc(cc1)C#N)n1cncn1
InchiKey: HPJKCIUCZWXJDR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7490 BRD-K88789588 HA1E 10 uM 6 h 0.23 0.98 0.09 0.0 0.0 0.0
7725 BRD-K88789588 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24624 BRD-K88789588 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25268 BRD-K88789588 PC3 10 uM 6 h 0.0 0.0 0.0 0.21 0.74 0.04
25440 BRD-K88789588 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91119 BRD-K88789588 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
121726 BRD-K88789588 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121827 BRD-K88789588 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.44
121878 BRD-K88789588 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129853 BRD-K88789588 HEK293 0.25 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.14
129883 BRD-K88789588 HELA 0.08 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
129903 BRD-K88789588 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
129978 BRD-K88789588 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.05
130064 BRD-K88789588 MDAMB231 0.03 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
130135 BRD-K88789588 THP1 0.08 uM 24 h -0.27 -1.11 0.37 -0.19 -0.64 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).