CMap Candidate Details

Structure:
CMap ID: C30587
Pert ID: BRD-K88807631
Compound Name: elacridar
Targets: ABCB1
MoA: P-glycoprotein inhibitor
SMILES: COc1cc2CCN(CCc3ccc(NC(=O)c4cccc5c4[nH]c4c(OC)cccc4c5=O)cc3)Cc2cc1OC
InchiKey: OSFCMRGOZNQUSW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96362 BRD-K88807631 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96433 BRD-K88807631 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121744 BRD-K88807631 HA1E 10 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
121808 BRD-K88807631 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121825 BRD-K88807631 MCF??7.00 10 uM 24 h 0.28 1.18 0.39 0.22 0.78 0.06
121875 BRD-K88807631 YAPC 10 uM 24 h 0.33 1.37 0.97 0.0 0.0 0.0
129850 BRD-K88807631 HEK293 0.03 uM 24 h -0.26 -1.08 0.29 0.0 0.0 0.0
129882 BRD-K88807631 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129975 BRD-K88807631 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130061 BRD-K88807631 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130132 BRD-K88807631 THP1 0.03 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).