CMap Candidate Details

Structure:
CMap ID: C30611
Pert ID: BRD-K88871508
Compound Name: lisuride
Targets: ADRA2A; ADRA2B; ADRA2C; DRD1; DRD2; DRD3; DRD4; DRD5; HTR1A; HTR1B; HTR1D; HTR2A; HTR2B; HTR2C
MoA: Dopamine receptor agonist
SMILES: CCN(CC)C(=O)N[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34
InchiKey: BKRGVLQUQGGVSM-RDTXWAMCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2937 BRD-K88871508 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3283 BRD-K88871508 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3647 BRD-K88871508 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3986 BRD-K88871508 VCAP 10 uM 6 h 0.18 0.76 0.0 -0.24 -0.82 0.15
39215 BRD-K88871508 A375 10 uM 6 h 0.0 0.0 0.0 0.26 0.91 0.23
39517 BRD-K88871508 A549 10 uM 6 h 0.23 0.95 0.06 0.0 0.0 0.0
39813 BRD-K88871508 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40102 BRD-K88871508 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.8 0.12
40655 BRD-K88871508 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40910 BRD-K88871508 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41233 BRD-K88871508 NPC 10 uM 24 h 0.19 0.81 0.0 -0.2 -0.69 0.02
41573 BRD-K88871508 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).