CMap Candidate Details

Structure:
CMap ID: C30666
Pert ID: BRD-K89014967
Compound Name: AS-703026
Targets: MAP2K1; MAP2K2
MoA: MEK inhibitor
SMILES: OC[C@@H](O)CNC(=O)c1ccncc1Nc1ccc(I)cc1F
InchiKey: VIUAUNHCRHHYNE-JTQLQIEISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33855 BRD-K89014967 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34207 BRD-K89014967 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34712 BRD-K89014967 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34989 BRD-K89014967 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.3 1.06 0.59
35635 BRD-K89014967 NEU 10 uM 24 h -0.21 -0.86 0.02 -0.29 -0.98 0.47
35862 BRD-K89014967 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36679 BRD-K89014967 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37016 BRD-K89014967 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90852 BRD-K89014967 MCF10A 3.33 uM 12 h 0.0 0.0 0.0 0.0 0.0 0.0
95989 BRD-K89014967 PHH 10 uM 24 h 0.3 1.25 0.54 0.33 1.18 0.98
97301 BRD-K89014967 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
121750 BRD-K89014967 HA1E 10 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
121780 BRD-K89014967 HELA 10 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
121813 BRD-K89014967 HT29 0.37 uM 24 h 0.14 0.59 0.0 0.0 0.0 0.0
121829 BRD-K89014967 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121857 BRD-K89014967 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121881 BRD-K89014967 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129774 BRD-K89014967 A375 2.22 uM 24 h 0.16 0.69 0.0 0.0 0.0 0.0
129858 BRD-K89014967 HEK293 0.74 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
129931 BRD-K89014967 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
130069 BRD-K89014967 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130140 BRD-K89014967 THP1 2.22 uM 24 h -0.33 -1.37 1.08 -0.3 -1.02 0.6
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).