CMap Candidate Details

Structure:
CMap ID: C30716
Pert ID: BRD-K89162000
Compound Name: tandutinib
Targets: FLT3; KIT; PDGFRA; PDGFRB
MoA: KIT inhibitor; FLT3 inhibitor; PDGFR inhibitor
SMILES: COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
InchiKey: UXXQOJXBIDBUAC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1148 BRD-K89162000 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1303 BRD-K89162000 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1380 BRD-K89162000 U2OS 10 uM 6 h 0.27 1.11 0.25 0.31 1.08 0.66
30579 BRD-K89162000 ASC 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
32250 BRD-K89162000 NEU 10 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
32551 BRD-K89162000 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33163 BRD-K89162000 SKB 10 uM 24 h 0.27 1.12 0.26 0.32 1.14 0.87
33516 BRD-K89162000 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
117655 BRD-K89162000 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117799 BRD-K89162000 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117849 BRD-K89162000 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127814 BRD-K89162000 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127853 BRD-K89162000 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127927 BRD-K89162000 HUVEC 10 uM 24 h 0.25 1.03 0.14 0.32 1.12 0.77
127981 BRD-K89162000 MCF10A 0.125 uM 24 h -0.16 -0.67 0.0 0.29 1.02 0.47
128071 BRD-K89162000 YAPC 10 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
135554 BRD-K89162000 HELA 0.08 uM 24 h -0.31 -1.29 0.77 0.4 1.43 2.21
135602 BRD-K89162000 HT29 0.03 uM 24 h -0.23 -0.96 0.1 -0.25 -0.85 0.19
135645 BRD-K89162000 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
135715 BRD-K89162000 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).