CMap Candidate Details

Structure:
CMap ID: C30879
Pert ID: BRD-K89626439
Compound Name: sirolimus
Targets: FKBP1A; MTOR
MoA: MTOR inhibitor
SMILES: CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=C/C=C/C=C(C)/[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O
InchiKey: QFJCIRLUMZQUOT-HPLJOQBZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25721 BRD-K89626439 A375 10 uM 6 h -0.2 -0.82 0.0 0.0 0.0 0.0
26011 BRD-K89626439 A549 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
26494 BRD-K89626439 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
26814 BRD-K89626439 HA1E 10 uM 6 h -0.26 -1.06 0.26 0.0 0.0 0.0
27115 BRD-K89626439 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27425 BRD-K89626439 HT29 10 uM 6 h -0.22 -0.91 0.05 0.36 1.29 1.49
27764 BRD-K89626439 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.15 -0.52 0.0
28055 BRD-K89626439 NEU 10 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
28374 BRD-K89626439 NPC 10 uM 24 h 0.2 0.82 0.0 -0.24 -0.8 0.12
28712 BRD-K89626439 PC3 10 uM 6 h -0.28 -1.18 0.51 0.0 0.0 0.0
29005 BRD-K89626439 PHH 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
29345 BRD-K89626439 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29557 BRD-K89626439 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).