CMap Candidate Details

Structure:
CMap ID: C30901
Pert ID: BRD-K89687904
Compound Name: PKCbeta-inhibitor
Targets: PRKCB
MoA: PKC inhibitor
SMILES: O=C1NC(=O)C(=C1Nc1ccccc1)c1cn(CCCn2ccnc2)c2ccccc12
InchiKey: KIWODJBCHRADND-UHFFFAOYSA-N
Compound Aliases: pkcbeta-inhibitor

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9004 BRD-K89687904 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9123 BRD-K89687904 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9538 BRD-K89687904 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9844 BRD-K89687904 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10093 BRD-K89687904 HA1E 10 uM 6 h 0.32 1.33 0.84 0.0 0.0 0.0
10220 BRD-K89687904 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
10620 BRD-K89687904 HCT116 10 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.37
10871 BRD-K89687904 HEPG2 10 uM 6 h -0.21 -0.88 0.03 0.0 0.0 0.0
11034 BRD-K89687904 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11220 BRD-K89687904 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11605 BRD-K89687904 NCIH2073 10 uM 6 h 0.27 1.15 0.32 0.0 0.0 0.0
11864 BRD-K89687904 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12161 BRD-K89687904 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12400 BRD-K89687904 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.64
12544 BRD-K89687904 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12893 BRD-K89687904 SW480 10 uM 6 h -0.31 -1.27 0.74 0.0 0.0 0.0
13072 BRD-K89687904 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13387 BRD-K89687904 U937 10 uM 6 h 0.25 1.02 0.13 0.29 1.03 0.52
13701 BRD-K89687904 VCAP 10 uM 6 h 0.0 0.0 0.0 0.31 1.08 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).