CMap Candidate Details

Structure:
CMap ID: C30910
Pert ID: BRD-K89708791
Compound Name: rifaximin
Targets: NR1I2
MoA: RNA synthesis inhibitor
SMILES: CO[C@H]1C=CO[C@@]2(C)Oc3c(C2=O)c2c4nc5cc(C)ccn5c4c(NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C
InchiKey: NZCRJKRKKOLAOJ-LGPAXTBISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24501 BRD-K89708791 A375 10 uM 6 h 0.28 1.15 0.32 0.0 0.0 0.0
24700 BRD-K89708791 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24820 BRD-K89708791 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.33
24965 BRD-K89708791 HT29 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
25053 BRD-K89708791 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25269 BRD-K89708791 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25442 BRD-K89708791 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).