CMap Candidate Details

Structure:
CMap ID: C30961
Pert ID: BRD-K89917372
Compound Name: retigabine
Targets: KCNQ2; KCNQ3; KCNQ5; KCNQ4
MoA: Potassium channel activator
SMILES: CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N
InchiKey: PCOBBVZJEWWZFR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127736 BRD-K89917372 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127779 BRD-K89917372 A549 1.11 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
127819 BRD-K89917372 HA1E 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
127859 BRD-K89917372 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.23 0.8 0.08
127933 BRD-K89917372 HUVEC 10 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
127987 BRD-K89917372 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128025 BRD-K89917372 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128047 BRD-K89917372 PC3 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
135560 BRD-K89917372 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135607 BRD-K89917372 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135651 BRD-K89917372 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135741 BRD-K89917372 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).